A pilot study of the immune response to whole inactivated avian influenza H7N1 virus vaccine in mice

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A pilot study of the immune response to whole inactivated avian influenza H7N1 virus vaccine in mice

BACKGROUND Highly pathogenic avian influenza (HPAI) outbreaks in domestic poultry bring humans into close contact with new influenza subtypes and represent a threat to human health. In 1999, an HPAI outbreak of H7N1 virus occurred in domestic poultry in Italy, and a wild-type virus isolate from this outbreak was chosen as a pandemic vaccine candidate. OBJECTIVES We conducted a pilot study to ...

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Immunogenicity of Concentrated and Purified Inactivated Avian Influenza Vaccine Formulation

Avian influenza (AI) H9N2 is a low pathogenic virus subtype belonging to Orthomyxoviridae family. Given the prevalence of this subtype as an infectious agent in poultry industry, special attention has been always directed toward the development of vaccine production against this infection. The vaccine of this infection is produced by killing the virus and using a mixture of inactivated antigen ...

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Experimental Study on the Pathogenicity of Avian Influenza A/Ch/It/5093/99(H7N1) Virus in Chicken

In this study, the pathogenicity of A/Ch/It/5093/1999 H7N1 which had been isolated from chicken during the outbreak in Italy was assessed in chicken by experimental infection virus. Ten SPF chickens of four week-old were inoculated with this virus, and five chickens were inoculated with uninfected allantoic fluid. For determination of virus shedding, oropharyngeal and cloacal swabs were taken f...

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evaluation of immune response against inactivated avian influenza (h9n2) vaccine, by using chitosan nanoparticles

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ژورنال

عنوان ژورنال: Influenza and Other Respiratory Viruses

سال: 2009

ISSN: 1750-2640,1750-2659

DOI: 10.1111/j.1750-2659.2009.00075.x